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PD1 Antibody
具体的参考文献 (1) RMB 10000(报价是含税价格)
Description：Rabbit polyclonal antibody to PD1
Application：WB
Reactivity：PD1 Antibody detects endogenous levels of total PD1.
Conjugate：Human, Mouse, Rat
Isotype：Rabbit
产品名称
PD1 Antibody
宿主
Rabbit
特异性
PD1 Antibody detects endogenous levels of total PD1.
经测试应用
适用于:WB
种属反应性
与反应:Human, Mouse, Rat
预测可用于:Pig, Bovine, Horse, Rabbit, Dog
预测可用于:Pig, Bovine, Horse, Rabbit, Dog
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).
产品名称
PD1 Antibody
宿主
Rabbit
特异性
PD1 Antibody detects endogenous levels of total PD1.
经测试应用
适用于:WB
种属反应性
与反应:Human, Mouse, Rat
预测可用于:Pig, Bovine, Horse, Rabbit, Dog
预测可用于:Pig, Bovine, Horse, Rabbit, Dog
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).
产品名称
PD1 Antibody
宿主
Rabbit
特异性
PD1 Antibody detects endogenous levels of total PD1.
经测试应用
适用于:WB
种属反应性
与反应:Human, Mouse, Rat
预测可用于:Pig, Bovine, Horse, Rabbit, Dog
预测可用于:Pig, Bovine, Horse, Rabbit, Dog
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).
产品名称
PD1 Antibody
宿主
Rabbit
特异性
PD1 Antibody detects endogenous levels of total PD1.
经测试应用
适用于:WB
种属反应性
与反应:Human, Mouse, Rat
预测可用于:Pig, Bovine, Horse, Rabbit, Dog
预测可用于:Pig, Bovine, Horse, Rabbit, Dog
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).
产品名称
PD1 Antibody
宿主
Rabbit
特异性
PD1 Antibody detects endogenous levels of total PD1.
经测试应用
适用于:WB
种属反应性
与反应:Human, Mouse, Rat
预测可用于:Pig, Bovine, Horse, Rabbit, Dog
预测可用于:Pig, Bovine, Horse, Rabbit, Dog
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).
