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HER3/ErbB3 Antibody
具体的参考文献 (1) RMB 10000(报价是含税价格)
Description：Rabbit polyclonal antibody to HER3/ErbB3
Application：WB IHC IF/ICC
Reactivity：HER3/ErbB3 Antibody detects endogenous levels of total ERBB3.
Conjugate：Human, Mouse, Rat
Isotype：Rabbit
产品名称
HER3/ErbB3 Antibody
宿主
Rabbit
特异性
HER3/ErbB3 Antibody detects endogenous levels of total ERBB3.
经测试应用
适用于:WB IHC IF/ICC
种属反应性
与反应:Human, Mouse, Rat
预测可用于:Pig, Bovine, Horse, Sheep, Rabbit, Dog
预测可用于:Pig, Bovine, Horse, Sheep, Rabbit, Dog
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
产品名称
HER3/ErbB3 Antibody
宿主
Rabbit
特异性
HER3/ErbB3 Antibody detects endogenous levels of total ERBB3.
经测试应用
适用于:WB IHC IF/ICC
种属反应性
与反应:Human, Mouse, Rat
预测可用于:Pig, Bovine, Horse, Sheep, Rabbit, Dog
预测可用于:Pig, Bovine, Horse, Sheep, Rabbit, Dog
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
产品名称
HER3/ErbB3 Antibody
宿主
Rabbit
特异性
HER3/ErbB3 Antibody detects endogenous levels of total ERBB3.
经测试应用
适用于:WB IHC IF/ICC
种属反应性
与反应:Human, Mouse, Rat
预测可用于:Pig, Bovine, Horse, Sheep, Rabbit, Dog
预测可用于:Pig, Bovine, Horse, Sheep, Rabbit, Dog
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
产品名称
HER3/ErbB3 Antibody
宿主
Rabbit
特异性
HER3/ErbB3 Antibody detects endogenous levels of total ERBB3.
经测试应用
适用于:WB IHC IF/ICC
种属反应性
与反应:Human, Mouse, Rat
预测可用于:Pig, Bovine, Horse, Sheep, Rabbit, Dog
预测可用于:Pig, Bovine, Horse, Sheep, Rabbit, Dog
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
产品名称
HER3/ErbB3 Antibody
宿主
Rabbit
特异性
HER3/ErbB3 Antibody detects endogenous levels of total ERBB3.
经测试应用
适用于:WB IHC IF/ICC
种属反应性
与反应:Human, Mouse, Rat
预测可用于:Pig, Bovine, Horse, Sheep, Rabbit, Dog
预测可用于:Pig, Bovine, Horse, Sheep, Rabbit, Dog
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
