服务热线
15852701687
Di-Methyl-Histone H3 (Lys27)/H3K27me2 Antibody
具体的参考文献 (1) RMB 10000(报价是含税价格)
Description：Rabbit polyclonal antibody to Di-Methyl-Histone H3 (Lys27)/H3K27me2
Application：WB IHC IF/ICC IP
Reactivity：Di-Methyl-Histone H3 (di methyl Lys27)/H3K27me2 Antibody detects endogenous levels of Di-Methyl-Histone H3 only when methylated at di methyl Lys27.
Conjugate：Human, Mouse, Rat
Isotype：Rabbit
产品名称
Di-Methyl-Histone H3 (Lys27)/H3K27me2 Antibody
宿主
Rabbit
特异性
Di-Methyl-Histone H3 (di methyl Lys27)/H3K27me2 Antibody detects endogenous levels of Di-Methyl-Histone H3 only when methylated at di methyl Lys27.
经测试应用
适用于:WB IHC IF/ICC IP
种属反应性
与反应:Human, Mouse, Rat
预测可用于:无
预测可用于:无
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin . The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination . These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression . In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20 . Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms . Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis . Phosphorylation at Thr3 of histone H3 is highly conserved among many species and is catalyzed by the kinase haspin. Immunostaining with phospho-specific antibodies in mammalian cells reveals mitotic phosphorylation at Thr3 of H3 in prophase and its dephosphorylation during anaphase .
产品名称
Di-Methyl-Histone H3 (Lys27)/H3K27me2 Antibody
宿主
Rabbit
特异性
Di-Methyl-Histone H3 (di methyl Lys27)/H3K27me2 Antibody detects endogenous levels of Di-Methyl-Histone H3 only when methylated at di methyl Lys27.
经测试应用
适用于:WB IHC IF/ICC IP
种属反应性
与反应:Human, Mouse, Rat
预测可用于:无
预测可用于:无
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin . The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination . These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression . In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20 . Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms . Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis . Phosphorylation at Thr3 of histone H3 is highly conserved among many species and is catalyzed by the kinase haspin. Immunostaining with phospho-specific antibodies in mammalian cells reveals mitotic phosphorylation at Thr3 of H3 in prophase and its dephosphorylation during anaphase .
产品名称
Di-Methyl-Histone H3 (Lys27)/H3K27me2 Antibody
宿主
Rabbit
特异性
Di-Methyl-Histone H3 (di methyl Lys27)/H3K27me2 Antibody detects endogenous levels of Di-Methyl-Histone H3 only when methylated at di methyl Lys27.
经测试应用
适用于:WB IHC IF/ICC IP
种属反应性
与反应:Human, Mouse, Rat
预测可用于:无
预测可用于:无
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin . The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination . These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression . In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20 . Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms . Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis . Phosphorylation at Thr3 of histone H3 is highly conserved among many species and is catalyzed by the kinase haspin. Immunostaining with phospho-specific antibodies in mammalian cells reveals mitotic phosphorylation at Thr3 of H3 in prophase and its dephosphorylation during anaphase .
产品名称
Di-Methyl-Histone H3 (Lys27)/H3K27me2 Antibody
宿主
Rabbit
特异性
Di-Methyl-Histone H3 (di methyl Lys27)/H3K27me2 Antibody detects endogenous levels of Di-Methyl-Histone H3 only when methylated at di methyl Lys27.
经测试应用
适用于:WB IHC IF/ICC IP
种属反应性
与反应:Human, Mouse, Rat
预测可用于:无
预测可用于:无
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin . The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination . These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression . In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20 . Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms . Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis . Phosphorylation at Thr3 of histone H3 is highly conserved among many species and is catalyzed by the kinase haspin. Immunostaining with phospho-specific antibodies in mammalian cells reveals mitotic phosphorylation at Thr3 of H3 in prophase and its dephosphorylation during anaphase .
产品名称
Di-Methyl-Histone H3 (Lys27)/H3K27me2 Antibody
宿主
Rabbit
特异性
Di-Methyl-Histone H3 (di methyl Lys27)/H3K27me2 Antibody detects endogenous levels of Di-Methyl-Histone H3 only when methylated at di methyl Lys27.
经测试应用
适用于:WB IHC IF/ICC IP
种属反应性
与反应:Human, Mouse, Rat
预测可用于:无
预测可用于:无
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin . The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination . These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression . In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20 . Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms . Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis . Phosphorylation at Thr3 of histone H3 is highly conserved among many species and is catalyzed by the kinase haspin. Immunostaining with phospho-specific antibodies in mammalian cells reveals mitotic phosphorylation at Thr3 of H3 in prophase and its dephosphorylation during anaphase .
