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LAMTOR1 Antibody
具体的参考文献 (1) RMB 10000(报价是含税价格)
Description：Rabbit polyclonal antibody to LAMTOR1
Application：WB IHC IF/ICC
Reactivity：LAMTOR1 Antibody detects endogenous levels of total LAMTOR1.
Conjugate：Human, Mouse, Rat
Isotype：Rabbit
产品名称
LAMTOR1 Antibody
宿主
Rabbit
特异性
LAMTOR1 Antibody detects endogenous levels of total LAMTOR1.
经测试应用
适用于:WB IHC IF/ICC
种属反应性
与反应:Human, Mouse, Rat预测可用于:Pig(100%), Bovine(%), Horse(%), Sheep(%), Rabbit(%), Dog(%)
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
产品名称
LAMTOR1 Antibody
宿主
Rabbit
特异性
LAMTOR1 Antibody detects endogenous levels of total LAMTOR1.
经测试应用
适用于:WB IHC IF/ICC
种属反应性
与反应:Human, Mouse, Rat预测可用于:Pig(100%), Bovine(%), Horse(%), Sheep(%), Rabbit(%), Dog(%)
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
产品名称
LAMTOR1 Antibody
宿主
Rabbit
特异性
LAMTOR1 Antibody detects endogenous levels of total LAMTOR1.
经测试应用
适用于:WB IHC IF/ICC
种属反应性
与反应:Human, Mouse, Rat预测可用于:Pig(100%), Bovine(%), Horse(%), Sheep(%), Rabbit(%), Dog(%)
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
产品名称
LAMTOR1 Antibody
宿主
Rabbit
特异性
LAMTOR1 Antibody detects endogenous levels of total LAMTOR1.
经测试应用
适用于:WB IHC IF/ICC
种属反应性
与反应:Human, Mouse, Rat预测可用于:Pig(100%), Bovine(%), Horse(%), Sheep(%), Rabbit(%), Dog(%)
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
产品名称
LAMTOR1 Antibody
宿主
Rabbit
特异性
LAMTOR1 Antibody detects endogenous levels of total LAMTOR1.
经测试应用
适用于:WB IHC IF/ICC
种属反应性
与反应:Human, Mouse, Rat预测可用于:Pig(100%), Bovine(%), Horse(%), Sheep(%), Rabbit(%), Dog(%)
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
