服务热线
15852701687
MSH2 Antibody
具体的参考文献 (1) RMB 10000(报价是含税价格)
Description：Rabbit polyclonal antibody to MSH2
Application：WB IHC IF/ICC
Reactivity：MSH2 Antibody detects endogenous levels of total MSH2.
Conjugate：Human, Mouse, Rat
Isotype：Rabbit
产品名称
MSH2 Antibody
宿主
Rabbit
特异性
MSH2 Antibody detects endogenous levels of total MSH2.
经测试应用
适用于:WB IHC IF/ICC
种属反应性
与反应:Human, Mouse, Rat
预测可用于:Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
预测可用于:Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between non-identical DNA sequences and induces both checkpoint and apoptotic responses following certain types of DNA damage (1). MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-α is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins and the Rad50-Mre11-NBS1 complex (2).Mutations in MSH2 have been found in a large proportion of hereditary non-polyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world (3). Mutations have also been associated with other sporadic tumors.
产品名称
MSH2 Antibody
宿主
Rabbit
特异性
MSH2 Antibody detects endogenous levels of total MSH2.
经测试应用
适用于:WB IHC IF/ICC
种属反应性
与反应:Human, Mouse, Rat
预测可用于:Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
预测可用于:Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between non-identical DNA sequences and induces both checkpoint and apoptotic responses following certain types of DNA damage (1). MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-α is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins and the Rad50-Mre11-NBS1 complex (2).Mutations in MSH2 have been found in a large proportion of hereditary non-polyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world (3). Mutations have also been associated with other sporadic tumors.
产品名称
MSH2 Antibody
宿主
Rabbit
特异性
MSH2 Antibody detects endogenous levels of total MSH2.
经测试应用
适用于:WB IHC IF/ICC
种属反应性
与反应:Human, Mouse, Rat
预测可用于:Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
预测可用于:Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between non-identical DNA sequences and induces both checkpoint and apoptotic responses following certain types of DNA damage (1). MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-α is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins and the Rad50-Mre11-NBS1 complex (2).Mutations in MSH2 have been found in a large proportion of hereditary non-polyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world (3). Mutations have also been associated with other sporadic tumors.
产品名称
MSH2 Antibody
宿主
Rabbit
特异性
MSH2 Antibody detects endogenous levels of total MSH2.
经测试应用
适用于:WB IHC IF/ICC
种属反应性
与反应:Human, Mouse, Rat
预测可用于:Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
预测可用于:Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between non-identical DNA sequences and induces both checkpoint and apoptotic responses following certain types of DNA damage (1). MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-α is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins and the Rad50-Mre11-NBS1 complex (2).Mutations in MSH2 have been found in a large proportion of hereditary non-polyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world (3). Mutations have also been associated with other sporadic tumors.
产品名称
MSH2 Antibody
宿主
Rabbit
特异性
MSH2 Antibody detects endogenous levels of total MSH2.
经测试应用
适用于:WB IHC IF/ICC
种属反应性
与反应:Human, Mouse, Rat
预测可用于:Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
预测可用于:Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
保存
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
描述
The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between non-identical DNA sequences and induces both checkpoint and apoptotic responses following certain types of DNA damage (1). MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-α is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins and the Rad50-Mre11-NBS1 complex (2).Mutations in MSH2 have been found in a large proportion of hereditary non-polyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world (3). Mutations have also been associated with other sporadic tumors.
